Cryo-electron microscopy (cryo-EM) is a powerful technique for determining high-resolution 3D biomolecular structures from imaging data. Its unique ability to capture structural variability has spurred the development of heterogeneous reconstruction algorithms that can infer distributions of 3D structures from noisy, unlabeled imaging data. Despite the growing number of advanced methods, progress in the field is hindered by the lack of standardized benchmarks with ground truth information and reliable validation metrics. Here, we introduce CryoBench, a suite of datasets, metrics, and benchmarks for heterogeneous reconstruction in cryo-EM. CryoBench includes five datasets representing different sources of heterogeneity and degrees of difficulty.

Deep learning-based fingerprinting is one of the current promising technologies for outdoor localization in cellular networks. However, deploying such localization systems for heterogeneous phones affects their accuracy as the cellular received signal strength (RSS) readings vary for different types of phones. In this paper, we introduce a number of techniques for addressing the phones heterogeneity problem in the deep-learning based localization systems. The basic idea is either to approximate a function that maps the cellular RSS measurements between different devices or to transfer the knowledge across them. Evaluation of the proposed techniques using different Android phones on four independent testbeds shows that our techniques can improve the localization accuracy by more than 220% for the four testbeds as compared to the state-of-the-art systems. This highlights the promise of the proposed device heterogeneity handling techniques for enabling a wide deployment of deep learning-based localization systems over different devices.

Federated Learning (FL) has emerged as a promising solution in Edge Computing (EC) environments to process the proliferation of data generated by edge devices. By collaboratively optimizing the global machine learning models on distributed edge devices, FL circumvents the need for transmitting raw data and enhances user privacy. Despite practical successes, FL still confronts significant challenges including constrained edge device resources, multiple tasks deployment, and data heterogeneity. However, existing studies focus on mitigating the FL training costs of each single task whereas neglecting the resource consumption across multiple tasks in heterogeneous FL scenarios. In this paper, we propose Heterogeneous Federated Learning with Local Parameter Sharing (FedLPS) to fill this gap. FedLPS leverages principles from transfer learning to facilitate the deployment of multiple tasks on a single device by dividing the local model into a shareable encoder and task-specific encoders. To further reduce resource consumption, a channel-wise model pruning algorithm that shrinks the footprint of local models while accounting for both data and system heterogeneity is employed in FedLPS. Additionally, a novel heterogeneous model aggregation algorithm is proposed to aggregate the heterogeneous predictors in FedLPS. We implemented the proposed FedLPS on a real FL platform and compared it with state-of-the-art (SOTA) FL frameworks. The experimental results on five popular datasets and two modern DNN models illustrate that the proposed FedLPS significantly outperforms the SOTA FL frameworks by up to 4.88% and reduces the computational resource consumption by 21.3%. Our code is available at:https://github.com/jyzgh/FedLPS.